Recombinant interleukin-1 stimulates clearance of Escherichia coli K1 bacteraemia.
作者： Sinikka Pelkonen , Gerd Pluschke
DOI: 10.1016/0882-4010(89)90083-1
关键词: Enterobacteriaceae 、 Interleukin 、 Spleen 、 Recombinant DNA 、 Microbiology 、 Escherichia coli 、 Immunity 、 Acute-phase protein 、 Biology 、 Ratón
摘要: Enhancement of non-specific resistance to neonatal Escherichia coli K1 infection by interleukin-1 (IL-1) was analysed. Recombinant human IL-1 administered prophylactically newborn LPS-non-responsive C3H/HeJ mice induced rapid clearance E. 018:K1 bacteraemia. The effect dose-dependent and observed with treated immediately 1 day before bacterial challenge, whereas treatment 2 days challenge ineffective. Clearance intravenously injected radiolabelled suggested that triggered defence mechanisms contribute sequestration killing in the spleen liver. Comparable increase occurred naturally resistant LPS-responsive had been subjected transient bacteraemia showed increased reinfection. In course a strong synthesis acute phase reactants both susceptible mouse strains, which indicated these proteins alone cannot confer natural K1. very proteins. when still viable IL-1-treated animals are not likely be major mediators IL-1-enhanced resistance.
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