Stool screening for colorectal cancer: molecular approaches.

摘要: Assay of molecular markers in stool represents a promising noninvasive approach to screen colorectal cancer. Given that neoplasms exfoliate abundantly into the lumen and DNA recovered from can be assayed with sensitive techniques, there is strong biologic rationale pursue this emerging technology. A challenge DNA-based testing relates selection markers. Because heterogeneity cancer, no single marker has yielded perfect sensitivity. Several combinations early assays have produced high detection rates both cancer advanced adenomas selected patient groups, but observations large representative populations are lacking at present. Potential expanded applications include supracolonic aerodigestive cancers dysplasia inflammatory bowel disease. Further discovery technologic refinements should translate improved test performance fuel continued evolution screening approach.