Time-Course Study of Gastric Damages in Rats by Anti-Inflammatory Drugs Using a Gastroscope and Its Quantification
作者： Akira FUJII , Noboru KUBOYAMA , Sumi KOBAYASHI , Yoshikazu NAMIKI , Toyoyuki TAMURA
DOI: 10.1254/JJP.48.317
关键词: Gastric mucosa 、 Stomach 、 Anti-inflammatory 、 Aspirin 、 Medicine 、 Fenoprofen Calcium 、 Ulcer index 、 Internal medicine 、 Pathology 、 Oral administration 、 Gastroenterology 、 Mefenamic acid
摘要: Time-course studies on gastric damages in rats caused by nonsteroidal anti-inflammatory drugs (NSAIDs) were performed using a gastroscope, and the readings quantified to obtain Congestion-Hemorrhage Index (CHI) for evaluating potencies of damaging properties NSAID. The correlation between CHI Ulcer (UI), value obtained conventional methods, was highly significant at 6 24 hr after forced oral administration peak CHIs aspirin (300 mg/kg), indomethacin (60 mefenamic acid mg/kg) fenoprofen calcium appeared approximately single drugs. Thus, it suggested that an observation addition one 7 might be necessary examination damaged mucosa. Under present experimental conditions, greatest mucosa among four NSAIDs. Mefenamic showed least potency mucosa, having smaller than aspirin. Indomethacin possessed stronger property
sci-hub.se 参考文章(20)
Kaito TSURUMI, Yasuzo HIRAMATSU, Masakatsu NOZAKI, Motohide HAYASHI, Tomohisa SHIBUYA, Hajime FUJIMURA, N-(2, 6-dichlorophenyl)-o-aminophenylacetic acidおよびそのNa塩ならびにN-(2, 6-dichlorophenyl)-anthranilic acidおよびそのNa塩の抗炎症作用:第2報 亜急性炎症について Folia Pharmacologica Japonica. ,vol. 69, pp. 299- 318 ,(1973) , 10.1254/FPJ.69.299
C V Winder, J Wax, L Scotti, F W Short, R A Scherrer, E M Jones, Anti-inflammatory, antipyretic and antinociceptive properties of N-(2,3-xylyl)anthranilic acid (mefenamic acid). Journal of Pharmacology and Experimental Therapeutics. ,vol. 138, pp. 405- 413 ,(1962)
André Robert, James E. Nezamis, Cleo Lancaster, Alexander J. Hanchar, Cytoprotection by Prostaglandins in Rats Prevention of Gastric Necrosis Produced by Alcohol, HCl, NaOH, Hypertonic NaCl, and Thermal Injury Gastroenterology. ,vol. 77, pp. 433- 443 ,(1979) , 10.1016/0016-5085(79)90002-7
Bergein F. Overholt, H. Marvin Pollard, Acetylsalicylic Acid and Ionic Fluxes Across the Gastric Mucosa of Man Gastroenterology. ,vol. 54, pp. 538- 542 ,(1968) , 10.1016/S0016-5085(68)80067-8
Judith A Wolfe, Richard Plotzker, Frank J Safina, Maria Ross, George Popky, Walter Rubin, Gastritis, Duodenitis, and Bleeding Duodenal Ulcer Following Mefenamic Acid Therapy Archives of Internal Medicine. ,vol. 136, pp. 923- 925 ,(1976) , 10.1001/ARCHINTE.1976.03630080057017
Koji TAKEUCHI, Osamu FURUKAWA, Hironori TANAKA, Hideyuki NISHIWAKI, Susumu OKABE, Impairment of Acid-Neutralizing Capacity and Lesion Formation in the Rat Duodenum during Hemorrhagic Shock: Comparative Study with Indomethacin Japanese Journal of Pharmacology. ,vol. 44, pp. 163- 170 ,(1987) , 10.1254/JJP.44.163
Koji TAKEUCHI, Hideyuki NISHIWAKI, Osamu FURUKAWA, Susumu OKABE, Cytoprotective Action of Histamine against 0.6 N HCl-Induced Gastric Mucosal Injury in Rats; Comparative Study with Adaptive Cytoprotection Induced by Exogenous Acid Japanese Journal of Pharmacology. ,vol. 44, pp. 335- 344 ,(1987) , 10.1254/JJP.44.335
S. H. FERREIRA, S. MONCADA, J. R. VANE, Indomethacin and aspirin abolish prostaglandin release from the spleen. Nature. ,vol. 231, pp. 237- 239 ,(1971) , 10.1038/NEWBIO231237A0
Yoh-ichi KUREBAYASHI, Takuya IKEDA, Yasuaki OSADA, Cytoprotective Action of Cetraxate against HCl·Ethanol-Induced Gastric Lesion in Rats Japanese Journal of Pharmacology. ,vol. 46, pp. 17- 25 ,(1988) , 10.1254/JJP.46.17
Susumu OKABE, Koji TAKEUCHI, Keita NAKAMURA, Keijiro TAKAGI, Pathogenesis of gastric lesions induced by aspirin in the pylorus-ligated rat. Japanese Journal of Pharmacology. ,vol. 24, pp. 363- 371 ,(1974) , 10.1254/JJP.24.363