Saccharomyces cerevisiae S288C genome annotation: a working hypothesis

摘要: The S. cerevisiae genome is the most well-characterized eukaryotic and one of simplest in terms identifying open reading frames (ORFs), yet its primary annotation has been updated continually decade since initial release 1996 (Goffeau et al., 1996). Saccharomyces Genome Database (SGD; www.yeastgenome.org) (Hirschman 2006), community-designated repository for this reference genome, strives to ensure that as accurate useful possible. At SGD, sequence are treated a working hypothesis, which must be repeatedly tested refined. In paper, celebration tenth anniversary completion sequence, we discuss ways have changed, consider multiple sources experimental comparative data on these changes based, describe our methods evaluating, incorporating documenting new data.