Risk of a Second Kidney Carcinoma Following Childhood Cancer: Role of Chemotherapy and Radiation Dose to Kidneys.
作者： Florent De Vathaire , Boris Scwhartz , Chiraz El-Fayech , Rodrigue Sètchéou Allodji , Bernard Escudier
DOI: 10.1016/J.JURO.2015.06.092
关键词: Childhood Cancer Survivor Study 、 Cancer 、 Medicine 、 Internal medicine 、 Oncology 、 Absolute risk reduction 、 Population 、 Retrospective cohort study 、 Kidney Carcinoma 、 Cumulative incidence 、 Incidence (epidemiology) 、 Gastroenterology
摘要: Purpose: Kidney carcinoma is a rare second malignancy following childhood cancer.Materials and Methods: We sought to quantify risk assess factors for kidney treatment cancer. evaluated cohort of 4,350 patients who were 5-year cancer survivors had been treated as children in France the United Kingdom. Patients between 1943 1985, followed an average 27 years. Radiation dose kidneys during was estimated with dedicated software, regardless site cancer.Results: developed 13 patients. The cumulative incidence 0.62% (95% CI 0.27%–1.45%) at 40 years after diagnosis, which 13.3-fold higher 7.1–22.3) than general population. absolute excess strongly increased longer duration followup (p <0.0001). Compared population, 5.7-fold 1.4–14.7)...
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