Progress and opportunities in molecular pathological epidemiology of colorectal premalignant lesions.

摘要: Molecular pathological epidemiology (MPE) is an integrative molecular and population health science that addresses the pathogenesis heterogeneity of disease processes. The MPE colonic rectal premalignant lesions (including hyperplastic polyps, tubular adenomas, tubulovillous villous traditional serrated sessile adenomas/sessile hamartomatous polyps) can provide unique opportunities for examining influence diet, lifestyle, environmental exposures on specific pathways carcinogenesis. Colorectal neoplasia a practical model by which both malignant epithelial tumor (carcinoma) its precursor are subjected to analyses. KRAS, BRAF, PIK3CA oncogene mutations, microsatellite instability, CpG island methylator phenotype, LINE-1 methylation commonly examined biomarkers. Future include interrogation comprehensive genomic, epigenomic, or panomic datasets, adoption in vivo pathology techniques. Considering colorectal continuum hypothesis emerging roles gut microbiota host immunity tumorigenesis, detailed information location important. There strengths caveats, especially with regard case ascertainment colonoscopy. identify etiologic associated neoplastic initiation progression, help us better understand carcinogenesis, facilitate personalized prevention, screening, therapy.