Consumption of beer and colorectal cancer incidence: a meta-analysis of observational studies.

作者: Cheng Zhang , Min Zhong

DOI: 10.1007/S10552-015-0532-5

关键词:

摘要: Several meta-analyses and reports from the World Cancer Research Fund supported a risk association between alcohol consumption colorectal cancer (CRC). However, for beer consumption, common type of alcoholic beverage, remains unclear. We identified studies by literature search PUBMED EMBASE through 30 June 2014. Summary relative risks (SRRs) with their 95 % CIs were calculated fixed or random effects model. Twelve case–control nine cohort included. Compared non-alcohol drinkers non-beer drinkers, any associated an increased CRC (SRR = 1.20, CI, 1.06–1.37; p heterogeneity <0.001, I 2 = 73.3 %), which was stronger in rectum than colon. The categorical meta-analysis indicated that heavy (≥2 drinks/day) drinking related to (SRR = 1.37, CI 1.26–1.49), while light moderate not. dose–response analysis demonstrated increase one drink per day (SRR = 1.13, 1.06–1.21). There evidence potential nonlinear intake incidence (p = 0.002 nonlinearity). results this suggest may be risk. More researches improved control confounding actual measurement are needed confirm these findings.

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