Role of heparan sulfate proteoglycans in cell signaling and cancer
作者： Erica M. Selva , Norbert Perrimon
DOI: 10.1016/S0065-230X(01)83003-7
关键词: Perlecan 、 Heparan sulfate 、 Syndecan 1 、 Transmembrane protein 、 Biochemistry 、 Golgi apparatus 、 Extracellular matrix 、 Biology 、 Signal transduction 、 Plasma protein binding
摘要: Publisher Summary Heparan sulfate proteoglycans (HSPGs) are composed of a protein core modified on specific serine residues by the addition heparan (HS) glucosaminoglycans (GAGs) synthesized in Golgi. Three distinct types proteins can serve as HSPG cores: transmembrane encoded syndecan genes, glycosylphosphatidylinositol (GPI) membrane-bound glypicans, and extracellular matrix secreted perlecan proteins. The chapter presents two major advances made understanding role HSPGs development cancer. First, studies Drosophila have identified many mutations either biosynthetic enzymes for example, Sugarless (Sgl), Sulfateless (Sfl), Tout velu (Ttv); or cores syndecans glypicans. Analysis mutant phenotypes has revealed critical roles modulating various growth factor signaling pathways. Second, linked to human cancers been isolated shown correspond defects biosynthesis HSPGs. explains importance cell provides insights into their functions. Modulating activity could influence caused aberrant signaling. concludes that constitute important targets therapeutics treat some tumors.
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sci-hub.se 参考文章(57)
Yohanns Bellaiche, Inge The, Norbert Perrimon, Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion Nature. ,vol. 394, pp. 85- 88 ,(1998) , 10.1038/27932
Caroline M. Alexander, Frieda Reichsman, Michael T. Hinkes, John Lincecum, Klaus A. Becker, Susan Cumberledge, Merton Bernfield, Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice Nature Genetics. ,vol. 25, pp. 329- 332 ,(2000) , 10.1038/77108
Xinhua Lin, Norbert Perrimon, Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling Nature. ,vol. 400, pp. 281- 284 ,(1999) , 10.1038/22343
Manabu Tsuda, Keisuke Kamimura, Hiroshi Nakato, Michael Archer, William Staatz, Bethany Fox, Melanie Humphrey, Sara Olson, Tracy Futch, Vesna Kaluza, Esther Siegfried, Lynn Stam, Scott B. Selleck, The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila Nature. ,vol. 400, pp. 276- 280 ,(1999) , 10.1038/22336
A. Bejsovec, A. Martinez Arias, Roles of wingless in patterning the larval epidermis of Drosophila. Development. ,vol. 113, pp. 471- 485 ,(1991) , 10.1242/DEV.113.2.471
Markku Salmivirta, Kerstin Lidholt, Ulf Lindahl, Heparan sulfate: a piece of information. The FASEB Journal. ,vol. 10, pp. 1270- 1279 ,(1996) , 10.1096/FASEBJ.10.11.8836040
S.-I. Higashijima, E. Shishido, Y. Emori, K. Saigo, Two FGF-receptor homologues of Drosophila: one is expressed in mesodermal primordium in early embryos Development. ,vol. 117, pp. 751- 761 ,(1993) , 10.1242/DEV.117.2.751
N. C. Leone, J. L. Shupe, E. J. Gardner, E. A. Millar, A. E. Olson, E. C. Phillips, Hereditary multiple exostosis A comparative human–equine–epidemiologic study Journal of Heredity. ,vol. 78, pp. 171- 177 ,(1987) , 10.1093/OXFORDJOURNALS.JHERED.A110351
Norbert Perrimon, The genetic basis of patterned baldness in Drosophila Cell. ,vol. 76, pp. 781- 784 ,(1994) , 10.1016/0092-8674(94)90351-4
Avner Yayon, Michael Klagsbrun, Jeffrey D. Esko, Philip Leder, David M. Ornitz, Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell. ,vol. 64, pp. 841- 848 ,(1991) , 10.1016/0092-8674(91)90512-W