作者: Hee-Young Jeon , Jun-Kyum Kim , Seok Won Ham , Se-Yeong Oh , Jaebong Kim
DOI: 10.1007/S13277-015-4439-2
关键词: Cell cycle 、 Survival rate 、 Phenotype 、 Senescence 、 Biology 、 Chemotherapy 、 Cell growth 、 Radiation therapy 、 Pathology 、 Cell aging
摘要: Glioblastoma multiforme (GBM) is one of the most aggressive and fatal primary brain tumors in humans. The standard therapy for treatment GBM surgical resection, followed by radiotherapy and/or chemotherapy. However, frequency tumor recurrence patients very high, survival rate remains poor. Delineating mechanisms essential therapeutic advances. Here, we demonstrate that irradiation rendered 17-20 % cells dead, but resulted 60-80 % growth-arrested with increases senescence markers, such as senescence-associated beta-galactosidase-positive cells, H3K9me3-positive p53-p21(CIP1)-positive cells. Moreover, induced expression secretory phenotype (SASP) mRNAs NFκB transcriptional activity Strikingly, compared to injection non-irradiated into immune-deficient mice, co-injection irradiated faster growth histological features human GBM. Taken together, our findings suggest senescent SASP after likely main reasons post-radiotherapy patients.