Polymorphisms in XPD and ERCC1 Associated with Colorectal Cancer Outcome.

摘要: Using the comprehensive approach to selecting polymorphisms date, we sought examine whether recurrence in colorectal cancer was associated with inherited variation three genes involved DNA repair and cell proliferation. Three polymorphisms, which are excision cross-complementation 1 (ERCC1), xeroderma pigmentosum group D (XPD) epidermal growth factor receptor (EGFR), were assessed 257 postoperative stage II/III CRC patients 5-fluorouracial chemotherapy Taiwan. In addition, correlations between genetic patients’ clinicopathological features investigated. Genotypes of XPD codon751 A/A ERCC1 codon118 T/T regional a statistically significant way (p = 0.018). Patients who carried AA TT genotypes demonstrated significantly greater risk (OR 5.625, 95% CI, 1.557–20.32). Inherited outcome As association single-nucleotide has not been studied previously cancer, these findings suggest novel sites variation, part explaining range treatment responses seen this disease.