Diagnosis of Bernard-Soulier syndrome and Glanzmann's thrombasthenia with a monoclonal assay on whole blood.
作者： R R Montgomery , T J Kunicki , C Taves , D Pidard , M Corcoran
DOI: 10.1172/JCI110780
关键词: Bernard–Soulier syndrome 、 Platelet disorder 、 Immunology 、 Thrombasthenia 、 Platelet membrane glycoprotein 、 Blood Platelet Disorders 、 Whole blood 、 Medicine 、 Blood sampling 、 Glanzmann's thrombasthenia
摘要: Two hereditary platelet disorders, Bernard-Soulier syndrome and Glanzmann's thrombasthenia, are characterized by selective deficiencies of membrane glycoproteins. Murine monoclonal antibodies were developed against glycoprotein Ib the IIb/IIIa complex. A rapid whole blood assay for deficiency these glycoproteins was used to study samples from six patients with thrombasthenia three syndrome. Patients type I II easily detectable this assay. This permits diagnosis disorders on 200 microliters within 2 h sampling.
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