Comparative Genome Structure, Secondary Metabolite, and Effector Coding Capacity across Cochliobolus Pathogens

摘要: The genomes of five Cochliobolus heterostrophus strains, two sativus three additional species (Cochliobolus victoriae, carbonum, miyabeanus), and closely related Setosphaeria turcica were sequenced at the Joint Genome Institute (JGI). datasets used to identify SNPs between strains species, unique genomic regions, core secondary metabolism genes, small secreted protein (SSP) candidate effector encoding genes with a view towards pinpointing structural elements gene content associated specificity these fungi different cereal hosts. Whole-genome alignment shows that percent each genome differs same while quarter species. On average, SNP counts among field isolates C. are more than 25× higher those inbred lines 50× lower suites nonribosomal peptide synthetase (NRPS), polyketide synthase (PKS), SSP–encoding astoundingly diverse but remarkably conserved whether or except for defining examples map regions. Functional analysis several strain-unique PKSs NRPSs reveal strong correlation role in virulence.