Phagocytosis by Human Monocytes of Particles Activating the Alternative Pathway of Complement
作者： E. JOHNSON , T. ESKELAND , K. BERTHEUSSEN
DOI: 10.1111/J.1365-3083.1984.TB00897.X
关键词: Phagocytosis 、 Zymosan 、 Alternative complement pathway 、 Molecular biology 、 C3-convertase 、 Agarose 、 Complement receptor 、 Red blood cell 、 Biochemistry 、 Monocyte 、 Biology
摘要: The phagocytosis of particles activating the alternative pathway complement by human monocytcs cultured under serum-free conditions was studied. In contrast to native zymosan particles, which were easily ingested, rabbit erythrocytes and agarose heads had be coated with C3b or C3bi engulfed monocytes. binding ingestion monocytes greater than for same equivalent amount C3b. uptake beads proportional on particles. activator C3b- C3bi-coated sheep erythrocytes, are non-activators, not ingested monocytes, although attachment took place. presence methylamine cobra venom factor, inhibitors, strongly reduced whereas only weakly affected. This suggests that is sensitive interference from a cell-derived C3 convertase (C3bBb). Binding activators via receptor(s) discussed.
sci-hub.se 参考文章(35)
D. M. Weir, Helga M. Ögmundsdóttir, S. C. Silverstein, J. W. M. van der Meer, Cellular Recognition by Phagocytes: Role of Lectin-Like Receptor(s) Mononuclear Phagocytes. pp. 865- 884 ,(1980) , 10.1007/978-94-009-8793-7_34
J. Michl, J. C. Unkeless, S. C. Silverstein, Z. A. Cohn, P. C. J. Leijh, Modulation of Macrophage Plasma Membrane Receptors for IgG and Complement Mononuclear Phagocytes. pp. 921- 940 ,(1980) , 10.1007/978-94-009-8793-7_36
P J Lachmann, R G Oldroyd, B W Wright, C Milstein, Three rat monoclonal antibodies to human C3. Immunology. ,vol. 41, pp. 503- 515 ,(1980)
C.H. Hammer, G.H. Wirtz, L. Renfer, H.D. Gresham, B.F. Tack, Large scale isolation of functionally active components of the human complement system. Journal of Biological Chemistry. ,vol. 256, pp. 3995- 4006 ,(1981) , 10.1016/S0021-9258(19)69557-8
K. Frank Austen, Joyce K. Czop, Douglas T. Fearon, Opsonin-Independent Phagocytosis of Activators of the Alternative Complement Pathway by Human Monocytes Journal of Immunology. ,vol. 120, pp. 1132- 1138 ,(1978)
J P Gorski, R Silversmith, S Fiebeger, T Moilanen, Covalent modification of fourth component of human complement with primary amines. Binding studies with metastable fragment C4b and with C4. Journal of Biological Chemistry. ,vol. 257, pp. 10948- 10954 ,(1982) , 10.1016/S0021-9258(18)33915-2
K F Austen, J K Czop, Functional discrimination by human monocytes between their C3b receptors and their recognition units for particulate activators of the alternative complement pathway. Journal of Immunology. ,vol. 125, pp. 124- 128 ,(1980)
J E Volanakis, A J Narkates, Interaction of C-reactive protein with artificial phosphatidylcholine bilayers and complement. Journal of Immunology. ,vol. 126, pp. 1820- 1825 ,(1981)
R. P. Levine, Douglas T. Fearon, S. K. Law, Action of the C3b-inactivator on the cell-bound C3b. Journal of Immunology. ,vol. 122, pp. 759- 765 ,(1979)
Kimishige Ishizaka, Thomas A. E. Platts-Mills, Activation of the Alternate Pathway of Human Complement by Rabbit Cells Journal of Immunology. ,vol. 113, pp. 348- 358 ,(1974)