Modulation of Macrophage Plasma Membrane Receptors for IgG and Complement

摘要: Ingestion of IgG-or complement-coated particles by phagocytic leukocytes can be divided into two discrete steps: attachment the particle to specific receptors on phagocyte’s plasma membrane and interiorization particle. The process is regulated distribution IgG or complement particle’s surface, availability for these ligands surface leukocyte. In effect, particle-bound provide templates which advances (Griffin et al. 1975, 1977). Particles such as bacteria have rigid cell walls capsules. Antibody molecules bound assume a relatively fixed geometry. Thus, if surfaces are make contact with their corresponding ligands, must considerable lateral mobility within plane membrane.