Leydig cell aging and the mechanisms of reduced testosterone synthesis
作者： Andrew S. Midzak , Haolin Chen , Vassilios Papadopoulos , Barry R. Zirkin
DOI: 10.1016/J.MCE.2008.07.016
关键词: Serum testosterone 、 Hormone 、 Leydig cell 、 Stimulation 、 Hypothalamic–pituitary–gonadal axis 、 Context (language use) 、 Luteinizing hormone 、 Testosterone (patch) 、 Endocrinology 、 Internal medicine 、 Biology
摘要: In males, serum testosterone levels decline with advancing age. Though part of a complex process, this age-related in appears to occur, part, due significant the ability aged Leydig cells produce maximally response luteinizing hormone (LH). The structure molecular machinery responsible for synthesis is described, and placed context cell biology. Multiple parameters related by have been observed change Relationships among these changes are reviewed. A discussion potential causes steroidogenic capacity presents model which inability adequately respond hormonal stimulation results cellular regression concomitant maximal output.
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