Dynamic action of DNA repair proteins as revealed by single molecule techniques: Seeing is believing
作者： Muwen Kong , Emily C. Beckwitt , Bennett Van Houten
DOI: 10.1016/J.DNAREP.2020.102909
关键词: Lesion 、 Cell biology 、 Nucleotide excision repair 、 DNA damage 、 Biology 、 DNA repair 、 DNA 、 Base excision repair 、 Molecule 、 PARP1 、 Biochemistry 、 Molecular biology
摘要: Abstract DNA repair is a highly dynamic process in which the actual damage recognition occurs through an amazing dance between duplex containing lesion and proteins. Single molecule investigations have revealed that proteins solve speed-stability paradox, of rapid search versus stable complex formation, by conformational changes induced both damaged Using Rad4, XPA, PARP1, APE1, OGG1 UV-DDB as examples, we discovered how these limit their travel on DNA, once encountered anomalous diffusion. We also observed PARP1 well or co-localize dynamically at sites near damage. This review highlights our group has greatly benefited from productive collaborations with Sam Wilson’s research group.
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