Genetic alterations of human brain tumors as molecular prognostic factors.
作者： Tetsuya Shiraishi , Kazuo Tabuchi
DOI: 10.1046/J.1440-1789.2003.00477.X
关键词: Procarbazine 、 Cancer research 、 Pathology 、 Astrocytoma 、 Carcinogenesis 、 Mdm2 、 Chemotherapy 、 Vincristine 、 Human brain 、 Brain tumor 、 Biology
摘要: Despite a number of basic and clinical studies, it is still very difficult to improve the prognosis patients with high-grade astrocytoma. However, recent success procarbazine, N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea vincristine (PCV) chemotherapy for oligodendrogliomas that have lost chromosomes 1p 19q has encouraged authors evaluate biological behavior brain tumors by means genetic analysis. Both disorders p53/MDM2/p14(ARF) p16(INK4a)/RB signaling pathways been found play an essential role in tumorigenesis various tumors. Herein, summarize alterations mainly focusing on two appear affect significantly patient prognosis.
sci-hub.se 参考文章(156)
Audrey S. Baur, Phil Shaw, Nathalie Burri, Françoise Delacrétaz, Fred T. Bosman, Pascal Chaubert, Frequent methylation silencing of p15INK4b (MTS2) and p16INK4a (MTS1) in B-cell and T-cell lymphomas Blood. ,vol. 94, pp. 1773- 1781 ,(1999) , 10.1182/BLOOD.V94.5.1773
Martina Schiebe, Petra Ohneseit, Wolfgang Hoffmann, R. Meyermann, Hans-Peter Rodemann, Michael Bamberg, Analysis of mdm2 and p53 gene alterations in glioblastomas and its correlation with clinical factors. Journal of Neuro-oncology. ,vol. 49, pp. 197- 203 ,(2000) , 10.1023/A:1006410702284
Andrey Korshunov, Andrey Golanov, Valery Timirgaz, Immunohistochemical markers for prognosis of ependymal neoplasms. Journal of Neuro-oncology. ,vol. 58, pp. 255- 270 ,(2002) , 10.1023/A:1016222202230
Jürgen A. Kraus, Matthias Wenghoefer, Nicole Glesmann, Svenja Mohr, Martina Beck, Matthias C. Schmidt, Rolf Schröder, Ute Berweiler, Wolfgang Roggendorf, Sabine Diete, Knut Dietzmann, Karlheinz Heuser, Bettina Müller, Rolf Fimmers, Andreas von Deimling, Uwe Schlegel, TP53 gene mutations, nuclear p53 accumulation, expression of Waf/p21, Bcl-2, and CD95 (APO-1/Fas) proteins are not prognostic factors in de novo glioblastoma multiforme. Journal of Neuro-oncology. ,vol. 52, pp. 263- 272 ,(2001) , 10.1023/A:1010684203704
Takashi Tamiya, Shinichiro Mizumatsu, Yasuhiro Ono, Tomoyasu Abe, Kengo Matsumoto, Tomohisa Furuta, Takashi Ohmoto, High cyclin E/low p27Kip1 expression is associated with poor prognosis in astrocytomas. Acta Neuropathologica. ,vol. 101, pp. 334- 340 ,(2001) , 10.1007/S004010000261
Matthias C. Schmidt, Sven Antweiler, Nina Urban, Wolf Mueller, A. Kuklik, Birgit Meyer-Puttlitz, Otmar D. Wiestler, David N. Louis, Rolf Fimmers, Andreas von Deimling, Impact of Genotype and Morphology on the Prognosis of Glioblastoma Journal of Neuropathology and Experimental Neurology. ,vol. 61, pp. 321- 328 ,(2002) , 10.1093/JNEN/61.4.321
Helena Miettinen, Juha Kononen, Pauli Sallinen, Hannu Alho, Pauli Helen, Heikki Helin, Hannu Kalimo, Leo Paljärvi, Jorma Isola, Hannu Haapasalo, CDKN2/p16 predicts survival in oligodendrogliomas : comparison with astrocytomas Journal of Neuro-oncology. ,vol. 41, pp. 205- 211 ,(1999) , 10.1023/A:1006185220369
David N. Louis, Eric C. Holland, J. Gregory Cairncross, Glioma Classification: A Molecular Reappraisal American Journal of Pathology. ,vol. 159, pp. 779- 786 ,(2001) , 10.1016/S0002-9440(10)61750-6
McLendon Re, Bigner Dd, Fuchs He, Friedman Ah, Rasheed Bk, Bigner Sh, Friedman Hs, Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25. Oncogene. ,vol. 10, pp. 2243- 2246 ,(1995)
Kazuhiro Nomura, Naohito Yamaguchi, Show Watanabe, The Statistical Analysis of Prognostic Factors for Brain Tumors Brain Tumor. pp. 29- 38 ,(1996) , 10.1007/978-4-431-66887-9_3