A metastatic nude-mouse model of human pancreatic cancer constructed orthotopically with histologically intact patient specimens

作者: X. Fu , F. Guadagni , R. M. Hoffman

DOI: 10.1073/PNAS.89.12.5645

关键词: Pancreatic tumorAdenocarcinomaPancreatic cancerMetastasisCancerImmunologyPancreasCA19-9PathologyPancreatic diseaseMedicine

摘要: … small sample of cases in nude mice involved 8 of these sites, resembling the clinical picture of pancreatic-cancer spread in the nude mice after orthotopic transplantation of intact tissue. …

参考文章(46)
Francesco M. Marincola, Bryan J. Drucker, Donald Y. Siao, Kathleen L. Hough, Walter D. Holder, The nude mouse as a model for the study of human pancreatic cancer. Journal of Surgical Research. ,vol. 47, pp. 520- 529 ,(1989) , 10.1016/0022-4804(89)90130-3
Seiji Naito, Raffaella Giavazzi, Shirley M. Walker, Kyogo Itoh, Joseph Mayo, Isaiah J. Fidler, Growth and metastatic behavior of human tumor cells implanted into nude and beige nude mice Clinical & Experimental Metastasis. ,vol. 5, pp. 135- 146 ,(1987) , 10.1007/BF00058059
Jeffrey Schlom, Alfredo Molinolo, Philip Noguchi, Ann Thor, David Wunderlich, Diane J. Poole, Raffaella Muraro, Masahide Kuroki, John W. Greiner, David Colcher, Jean F. Simpson, Generation and Characterization of B72.3 Second Generation Monoclonal Antibodies Reactive with the Tumor-associated Glycoprotein 72 Antigen Cancer Research. ,vol. 48, pp. 4588- 4596 ,(1988)
Robert S. Bresalier, Steven E. Raper, Erkki S. Hujanen, Young S. Kim, A new animal model for human colon cancer metastasis International Journal of Cancer. ,vol. 39, pp. 625- 630 ,(1987) , 10.1002/IJC.2910390514
Jeffrey Schlom, Patricia H. Hand, Philip D. Fernsten, Paul F. Robbins, Judith A. Kantor, Michael Salgaller, Transduction and Expression of the Human Carcinoembryonic Antigen Gene in a Murine Colon Carcinoma Cell Line Cancer Research. ,vol. 51, pp. 3657- 3662 ,(1991)
David M. Segal, Julie A. Titus, David A. Stephany, Fluorescence flow cytometry in the study of lymphoid cell receptors Immunochemical Techniques Part K: In Vitro Models of B and T Cell Functions and Lymphoid Cell Receptors. ,vol. 150, pp. 478- 492 ,(1987) , 10.1016/0076-6879(87)50101-X
Isaiah J. Fidler, Shirley M. Walker, Kiyoshi Morikawa, J. Milburn Jessup, In Vivo Selection of Highly Metastatic Cells from Surgical Specimens of Different Primary Human Colon Carcinomas Implanted into Nude Mice Cancer Research. ,vol. 48, pp. 1943- 1948 ,(1988)
A P Kyriazis, J D Stinnett, G J Michael, L DiPersio, A J Pesce, Growth patterns and metastatic behavior of human tumors growing in athymic mice. Cancer Research. ,vol. 38, pp. 3186- 3190 ,(1978)