Interaction of Salmonella Typhimurium with Dendritic Cells Derived from Pluripotent Embryonic Stem Cells
作者： Raffaella Rossi , Christine Hale , David Goulding , Robert Andrews , Zarah Abdellah
DOI: 10.1371/JOURNAL.PONE.0052232
关键词: Endothelial stem cell 、 Follicular dendritic cells 、 Antigen 、 Molecular biology 、 Embryonic stem cell 、 Stem cell marker 、 T cell 、 Cell biology 、 Biology 、 Antigen presentation 、 Cellular differentiation 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: Using an in vitro differentiation protocol we isolated cells with the properties of dendritic (DCs) from immunologically refractive pluripotent murine embryonic stem (ESCs). These ES-derived (ESDCs) expressed cytokines and were able to present antigen a T cell line. Infection ESDCs Salmonella Typhimurium stimulated expression immune markers thousands genes, many associated response. Consequently, this system provides novel model, amenable genetic modification, for monitoring host/pathogen interactions.
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