The influence of central hyperosmotic solutions on drinking and vasopressin release following peripheral hyperosmotic NaCl in the minipig

摘要: The drinking and lysine vasopressin (LVP, porcine vasopressin) responses were measured in minipigs given simultaneous intracarotid (i.c.) (1.28 ml/min) intracerebroventricular (i.c.v.) (50 microliters/min) infusions of solutions differing osmolality sodium content. Observations made during, for a further 15 min after, the combined which lasted min. Drinking response to i.c. infusion 2.0 Osm NaCl started with latency 7 was unaffected by i.c.v. 0.15 M NaCl, additive produced 1.4 sucrose or mannitol, inhibited urea. LVP release following hyperosmotic observed as early first blood sample, at 2 min, attenuated urea attenuated, then slightly augmented, non-electrolyte solutions. These results show that peripheral administration an osmotic stimulus minipig can add induced central would have increased effective pressure cerebrospinal fluid (CSF) but may decreased CSF concentration. By contrast, stimulated Thus, minipigs, separate osmoreceptors appear mediate osmotically release.