作者: Tapas Chakraborty , Yasushi Shibata , Lin-Yan Zhou , Yoshinao Katsu , Taisen Iguchi
DOI: 10.1016/J.MCE.2010.12.002
关键词: Endocrinology 、 Estrogen receptor 、 Sexual differentiation 、 Hatching 、 Embryo 、 Oocyte 、 Differential expression 、 Biology 、 Oryzias 、 Embryogenesis 、 Internal medicine
摘要: Abstract In fish, estradiol-17β (E2) regulates various reproductive processes by acting through estrogen receptors (ERs). Here, we cloned three ER subtypes from medaka and examined their developmental expression in the gonads liver of genetically females males embryos to adults. During embryogenesis, marked increases ERβ2, but not either ERα or ERβ1, were found female during sex differentiation. E2 treatment induced up-regulation ERβ2 male embryos. adult ovaries, levels high follicles (granulosa cells) oocyte growth. testis, ERβ1 exhibited a distinct peak at 10 days post hatching (dph). liver, very both throughout sampling period with significantly higher 30–50 dph. These findings suggest each action be mediated different types ERs.