Deep vein thrombosis and pulmonary embolism among hospitalized coronavirus disease 2019-positive patients predicted for higher mortality and prolonged intensive care unit and hospital stays in a multisite healthcare system.

摘要: OBJECTIVE: We assessed the incidence of deep vein thrombosis (DVT) and pulmonary embolism (PE) in hospitalized patients with coronavirus disease 2019 (COVID-19) compared that a matched cohort similar cardiovascular risk factors effects DVT PE on hospital course. METHODS: performed retrospective review prospectively collected data from COVID-19 who had been March 11, 2020 to September 4, 2020. The were randomly 1:1 ratio by age, sex, admission, smoking history, diabetes mellitus, coronary artery without COVID-19. primary endpoint was DVT/PE odds developing using conditional logistic regression model. secondary hospitalization outcomes for DVT/PE, including mortality, intensive care unit (ICU) ICU stay, length (LOH). Multivariable analysis identify variables associated discharge disposition, duration, LOH. RESULTS: A total 13,310 tested positive COVID-19, 915 whom (6.9%) across our multisite health system. mean age 60.8 ± 17.0 years, 396 (43.3%) women. Of patients, 82 (9.0%) diagnosis confirmed ultrasound examination extremities and/or computed tomography angiography chest. presenting setting infection greater than (0.6% [5 915] vs 9.0% [82 915]; [OR], 18; 95% confidence interval [CI], 8.0-51.2; P < .001). vascular not different between DVT/PE. Mortality (P = .02), need stay (P < .001), duration LOH .001) On multivariable analysis, hemoglobin (OR, 0.71; CI, 0.46-0.95; P = .04) D-dimer 1.0; 0.33-1.56; .03) levels higher mortality. Higher activated partial thromboplastin times 1.1; 1.00-1.12; P = .03) interleukin-6 (IL-6) 1.01-1.07; .05) admission. IL-6 1.00-1.02; rehabilitation placement after discharge. gamma (coefficient, -3.0; 0.03-0.08; .005) prolonged time (coefficient, 2.0; 0.003-0.006; .05), international normalized (coefficient, -3.2; 0.06-0.19; .002) 2.4; 0.0011-0.0027; .02) CONCLUSIONS: significantly occurred COVID-19-positive non-COVID-19 factors. Patients affected more likely experience require stays Advancements prevention are needed infection.