Natural history of chronic hepatitis B virus infection from infancy to adult life - the mechanism of inflammation triggering and long-term impacts.
作者： Jia-Feng Wu , Mei-Hwei Chang
DOI: 10.1186/S12929-015-0199-Y
关键词: Hepatocellular carcinoma 、 HBeAg 、 Hepatitis B 、 Cirrhosis 、 Medicine 、 Virology 、 Hepatitis B virus 、 Immunology 、 Seroconversion 、 Virus 、 Hepatitis
摘要: Chronic hepatitis B virus (HBV) infection in endemic areas usually starts since infancy and early childhood persists lifelong. The clinical course varies among different chronic infected subjects. Majority of HBV children present with immune-tolerant status initially, experience the immune clearance phase various degree liver injury during or beyond puberty, then enter inactive after e antigen (HBeAg) seroconversion. Part them may have DNA titers elevation flare HBeAg seroconversion, so call HBeAg-negative flare. Liver cirrhosis, even hepatocellular carcinoma develop afterward.
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