The Effects of Cytokines on Spontaneous Hepatitis B Surface Antigen Seroconversion in Chronic Hepatitis B Virus Infection

摘要: We examined the role of human cytokines in natural course hepatitis B surface Ag (HBsAg) seroconversion chronic virus (HBV) infection. The clinical spontaneous HBsAg was assessed 296 chronically HBV-infected patients. Single nucleotide polymorphisms (SNPs) IL-1β, IL-2, IL-4, IL-10, IL-12β, IL-13, IL-27, and IFN-γ genes were patients another 193 HBV recoverers. a determinant sequence subjects with without also analyzed. start immune-clearance phase (serum alanine aminotransferase levels > 30 IU/l) before age 48 mo e (HBeAg) 10 y predicted (odds ratios 17.7 5.0; p < 0.001 0.002, respectively). A-allele IL-10 SNP rs1800872 associated higher serum levels, G-allele IL-12β rs3212217 sustained high IL-12p70 during phase. Both predictors recovery 4.0 26.3; = 0.002 0.001, Spontaneous not related to sex, genotype, or mutation. phase, at HBeAg seroconversion, IL-12 are infection, predictive recovery.