Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats
作者： Orsolya Kántor , Yasin Temel , Carsten Holzmann , Kerstin Raber , Huu-Phuc Nguyen
DOI: 10.1016/J.NBD.2005.12.014
关键词: Stereology 、 Striatum 、 Psychology 、 Huntington's disease 、 Transgene 、 Function (biology) 、 Cortex (botany) 、 Neuron loss 、 Neuroscience 、 Striatal neuron
摘要: Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by selective striatal neuron loss and motor, cognitive affective disturbances. The present study aimed to test the hypothesis of adult-onset in striatum frontal cortical layer V as well alterations behavior pointing impaired function a recently developed transgenic rat model HD (tgHD rats) exhibiting enlarged ventricles, atrophy pycnotic pyramidal cells V. High-precision design-based stereological analysis revealed reduced mean total number neurons but not 12-month-old tgHD rats compared with age-matched wild-type controls. No numbers were found 6-month-old animals. Testing 14-month-old animals choice reaction time task indicated
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