Modulatory effects of Moringa oleifera extracts against hydrogen peroxide-induced cytotoxicity and oxidative damage.

摘要: Studies have demonstrated that the induction of oxidative stress may be involved in DNA damage. The present study examined and assessed hydrogen peroxide (H(2)O(2))-mediated damage human tumor KB cells also ability Moringa oleifera leaf extracts to inhibit H(2)O(2) imposed a on membrane lipids which was quantified by extent thiobarbituric acid reactive substances (TBARS) formed. caused very significant inhibition LPO formation enhanced activity antioxidative enzymes such as superoxide dismutase (SOD) catalase (CAT) cells. comet assay employed its extracts. increase number bearing comets, resulting significantly reduced incidence comets oxidant stressed cytotoxicity presence absence studied MTT showed marked decrease viability where effectively increased assaulted observed cytoprotective is probably due antioxidant properties constituents, mainly phenolics. Total phenolics higher correlation with activity. than reference compound. These results suggest could attributed their free radical scavenging activities effect evidenced can part correlated modulation redox-sensitive mechanisms.