Retinoprotective effects of Moringa oleifera via antioxidant, anti-inflammatory, and anti-angiogenic mechanisms in streptozotocin-induced diabetic rats.
作者： Suresh Kumar Gupta , Binit Kumar , B.P. Srinivasan , Tapas Chandra Nag , Sushma Srivastava
关键词: Vascular endothelial growth factor 、 Interleukin 、 Streptozotocin 、 Superoxide dismutase 、 Retinal 、 Pharmacology 、 Biochemistry 、 Fluorescein angiography 、 Protein kinase C 、 Tumor necrosis factor alpha 、 Medicine
摘要: Abstract Purpose: The present study was aimed to evaluate the retinoprotective effects of Moringa oleifera (MO) in Streptozotocin-induced diabetic rats. Methods: continued for 24 weeks and evaluated inflammatory (tumor necrosis factor [TNF]-α interleukin [IL]-1β, angiogenic (vascular endothelial growth [VEGF] protein kinase C [PKC]-β) antioxidant (Glutathione, Superoxide dismutase, Catalase) parameters. Retinal leakage checked by Fluorescein angiography (FA) fundus photographs were retinal vessel caliber (arteriolar venular). Transmission electron microscopy done determine basement membrane (BM) thickness. Results: results showed potential hypoglycemic MO. In study, a significant rise expression (TNF-α IL-1β) (VEGF PKC-β) parameters observed retinae as compared normal retinae. However, MO-t...
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