Clinical and epidemiological features of an outbreak of acinetobacter infection in an intensive therapy unit

摘要: Surmmary Sporadic examples of infection with multi-resistant Acinetobacter spp. have occurred in Nottingham hospitals since at least 1977, punctuated by more prolonged outbreaks involving larger numbers patients, particularly those confined to the intensive therapy unit (ITU) severe underlying disease. In most recent outbreak, 11 patients were infected strains and 26 colonised. Four died directly or indirectly from spp., either while ITU after discharge a general ward. The mean interval admission first isolation strain was 6·7 12·1 days colonised groups, respectively. Multi-resistant isolated frequently respiratory tract, eight had probable suspected pneumonia caused sp. All treated imipenem, without an aminoglycoside, except one patient who before diagnosis acinetobacter confirmed. various environmental sites ITU, isolates found be related closely biotyping, antibiograms, pulsed-field gel electrophoresis chromosomal fingerprints ribotyping. outbreak controlled ultimately transfer cubicle, cohort nursing, emphasis on importance hand washing contact when handling case notes, use disposable aprons gowns during contact. These measures combined closure for decontamination purposes two separate occasions. Continued surveillance occasional sampling has proved important preventing controlling subsequent this increasingly nosocomial pathogen.