Different expression patterns of cyclins A, D1 and E in human colorectal cancer.
作者： Aijin Wang , Naoki Yoshimi , Masumi Suzui , Akiji Yamauchi , Makoto Tarao
DOI: 10.1007/BF01226270
关键词: Cyclin D1 、 Cancer research 、 Cyclin E 、 Cyclin A 、 Cancer 、 Cyclin D 、 Cyclin B 、 Biology 、 Cyclin 、 Carcinogenesis
摘要: The expressions of cyclins A, D1 and E at the protein level were investigated by Western blotting in human colorectal carcinomas adjacent non-neoplastic mucosas. Cyclin was higher cancer tissue than mucosa 92% patients (35 out 38 cases). However, cyclin A expression that 63% (25 40 cases) cases, only 4 (10%) cancers had expression. Eleven (27%) demonstrated equivalent to mucosa. Equal mucosal tissues found 51% cases (20/39), lower 41% (16/39) three showed Proliferating-cell nuclear antigen immunohistochemistry revealed labeling index 43.5±8.3% while 14.8±5.1%. These results proved express high levels E, consistent with a rate cell proliferation, whereas most such lose control
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