Ultrastructural localization of pemphigus vulgaris and pemphigus foliaceus antigens in cultured human squamous carcinoma cells.
作者： M. AKIYAMA , T. HASHIMOTO , M. SUGIURA , T. NISHIKAWA
DOI: 10.1111/J.1365-2133.1991.TB14746.X
关键词: Squamous carcinoma 、 Extracellular 、 Pemphigus vulgaris 、 Pathology 、 Antigen 、 Immunogold labelling 、 Cell culture 、 Immunohistochemistry 、 Pemphigus foliaceus 、 Biology
摘要: The ultrastructural localization of the pemphigus vulgaris (PV) and foliaceus (PF) antigens in cultured human squamous carcinoma cells was observed using immunogold electron microscopy. Both PV PF autoantibodies bound only to extracellular portion desmosomal structures. After incubation at 37 degrees C, antigen-antibody complexes were within cells. antigen expression markedly reduced when medium with a low Ca2+ concentration.
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