The role of CA3 GABAA receptors on anxiolytic-like behaviors and avoidance memory deficit induced by NMDA receptor antagonists

摘要: Cognitive functions are influenced by memory and anxiety states. However, a non-linear relation has been shown between these two domains. The important role of the hippocampus in emotional responses may link pathogenesis to memory-related GABAergic glutamatergic processes hippocampus. To investigate GABAA receptors blocking N-methyl-D-aspartate (NMDA) CA3 region, balancing system activities as an approach for management related disorders, elevated plus-maze test-retest paradigm was used anxiolytic-like state on test day avoidance retest day. data showed that injection D-AP5, NMDA receptor antagonist, induced behavior impaired memory. Injection agonist (muscimol), but not antagonist (bicuculline), impairment. Neither muscimol nor bicuculline altered anxiety-like behaviors. Muscimol pretreatment did change D-AP5-induced behaviors potentiated Bicuculline blocked contradicted its effect Our findings indicate alteration activity can effectively affect deficit D-AP5.