Validation of FDG‐PET/MRI coregistration in nonlesional refractory childhood epilepsy

摘要: Summary Purpose:  To validate the use of 18F-fluorodeoxyglucose–positron emission tomography/magnetic resonance imaging (FDG-PET/MRI) coregistration for epileptogenic zone detection in children with MRI nonlesional refractory epilepsy and to assess its ability guide a second interpretation studies. Methods:  Thirty-one whose results were included prospectively. All patients underwent presurgical evaluation following standard protocol our unit, which FDG-PET FDG-PET/MRI coregistration. Cerebral areas decreased uptake PET PET/MRI fusion images compared visually then contrasted presumed localization, had been obtained from other clinical data. A studies was carried out, focusing on exact anatomic region hypometabolism located images. Key Findings:  Both detected 67.8% patients, good concordance subject basis cerebral involved (κ statistic = 0.83 0.79, respectively). Hypometabolism by single PET, as well images, same hemisphere, indicated electroclinical data 58% at place 39% cases. Of who showed PET/MRI, 43% also experienced changes guided interpretation, subtle-lesional. Significance:  is an variant that least accurate alone detecting pediatric can look previously reported nonlesional, turning meaningful percentage into subtle-lesional.