Cholecystokinin release and biliopancreatic secretion in response to selective perfusion of the duodenal loop with aminoacids in man.
作者： J F Colombel , A Sutton , J A Chayvialle , R Modigliani
关键词: Duodenum 、 Internal medicine 、 Distension 、 Cholecystokinin 、 Small intestine 、 Arginine 、 Perfusion 、 Biology 、 Gastrointestinal hormone 、 Pancreas 、 Endocrinology
摘要: The aim of this study was to measure the role duodenal loop in biliopancreatic secretion man by infusing various stimuli at ampulla Vater and collecting contents ligament Treitz, above an occluding balloon. Perfusion 10 ml/min a first mixture aminoacids - phenylalanine (47.2 mmol), methionine (38.2 tryptophan (11 valine (61.6 mmol) increased cholecystokinin (CCK) plasma concentrations bile salt output (p less than 0.005) as compared with control electrolyte solution, but did not change pancreatic enzyme significantly; infusion another aminoacid arginine (32.4 histidine (14.1 leucine (36 isoleucine (21.5 lysine (31 threonine (23 CCK concentrations, or output. respective distension endogenous investigated perfusing solution 2, 5, ml/min. Changing perfusion rate from 2 5 led significant increase 0.01) no further Bile influenced solution. During despite stepwise release, only lipase 0.05) when raised Our results suggest that release (1) depends on nature (2) has predominant regulation low is effective superimposed mechanical stimulus caused (3) major for gall bladder contraction which distension.
sci-hub.se 参考文章(19)
Cornelius P. Dooley, Jorge E. Valenzuela, Duodenal volume and osmoreceptors in the stimulation of human pancreatic secretion Gastroenterology. ,vol. 86, pp. 23- 27 ,(1984) , 10.1016/0016-5085(84)90585-7
Robert S. Fisher, Elizabeth Rock, Leon S. Malmud, Cholinergic effects on gallbladder emptying in humans Gastroenterology. ,vol. 89, pp. 716- 722 ,(1985) , 10.1016/0016-5085(85)90564-5
F.B. Thomas, D. Sinar, E.L. Mazzaferri, S. Cataland, H.S. Mekhjian, J.H. Caldwell, J.J. Fromkes, Selective release of gastric inhibitory polypeptide by intraduodenal amino acid perfusion in man. Gastroenterology. ,vol. 74, pp. 1261- 1265 ,(1978) , 10.1016/0016-5085(78)90703-5
C. Guedon, P. Ducrotte, J. A. Chayvialle, E. Lerebours, P. Denis, R. Colin, Effects of intravenous and intraduodenal fat on jejunal motility and on plasma cholecystokinin in man Digestive Diseases and Sciences. ,vol. 33, pp. 558- 564 ,(1988) , 10.1007/BF01798357
S. Watanabe, K. Shiratori, T. Takeuchi, W. Y. Chey, C. H. You, T. -M. Chang, Release of cholecystokinin and exocrine pancreatic secretion in response to an elemental diet in human subjects. Digestive Diseases and Sciences. ,vol. 31, pp. 919- 924 ,(1986) , 10.1007/BF01303211
G. Marchis-Mouren, L. Sarda, P. Desnuelle, Purification of hog pancreatic lipase. Archives of Biochemistry and Biophysics. ,vol. 83, pp. 309- 319 ,(1959) , 10.1016/0003-9861(59)90036-0
VAY LW Go, Alan F Hofmann, WHJ Summerskill, None, Pancreozymin bioassay in man based on pancreatic enzyme secretion: potency of specific amino acids and other digestive products Journal of Clinical Investigation. ,vol. 49, pp. 1558- 1564 ,(1970) , 10.1172/JCI106373
William R. Brugge, Catherine A. Burke, Richard S. Izzo, Melvin Praissman, Role of cholecystokinin in intestinal phase of human pancreatic secretion Digestive Diseases and Sciences. ,vol. 32, pp. 155- 163 ,(1987) , 10.1007/BF01297103
D. Fourmy, L. Pradayrol, H. Antoniotti, J. P. Esteve, A. Ribet, Purification of Radio-Iodinated Cholecystokinin Peptides by Reverse Phase HPLC Journal of Liquid Chromatography & Related Technologies. ,vol. 5, pp. 757- 766 ,(1982) , 10.1080/01483918208060584
Richard S. Izzo, William R. Brugge, Melvin Praissman, Immunoreactive cholecystokinin in human and rat plasma: correlation of pancreatic secretion in response to CCK Regulatory Peptides. ,vol. 9, pp. 21- 34 ,(1984) , 10.1016/0167-0115(84)90004-1