Calcium-sensing receptor mediates phenylalanine-induced cholecystokinin secretion in enteroendocrine STC-1 cells
作者： Tohru Hira , Shingo Nakajima , Yuzuru Eto , Hiroshi Hara
DOI: 10.1111/J.1742-4658.2008.06604.X
关键词:
摘要: Intraluminal l‐phenylalanine (Phe) stimulates cholecystokinin (CCK) secretion in vivo and in vitro. However, the cellular mechanism by which CCK‐producing enteroendocrine cells sense Phe is unknown. The calcium‐sensing receptor (CaR) can sense amino acids, and is expressed in the gastrointestinal tract. In the present study, we examined whether CaR functions as a receptor for Phe in CCK‐producing enteroendocrine cells. CCK secretion and intracellular Ca2+ concentration in response to Phe were measured in the murine CCK …
sci-hub.se 参考文章(21)
P Kirchhoff, JP Geibel, Role of calcium and other trace elements in the gastrointestinal physiology. World Journal of Gastroenterology. ,vol. 12, pp. 3229- 3236 ,(2006) , 10.3748/WJG.V12.I20.3229
Irmtraut Koop, Alison M.J. Buchan, Cholecystokinin release from isolated canine epithelial cells in short-term culture Gastroenterology. ,vol. 102, pp. 28- 34 ,(1992) , 10.1016/0016-5085(92)91780-8
Eric G. Delmar, Maxine Gowen, Rebecca L. Conklin, John Fox, William L. Heaton, Michael A. Miller, Pradip K. Bhatnagar, Lyssa D. Lambert, Edward F. Nemeth, John G. Gleason, Calcilytic Compounds: Potent and Selective Ca2+Receptor Antagonists That Stimulate Secretion of Parathyroid Hormone Journal of Pharmacology and Experimental Therapeutics. ,vol. 299, pp. 323- 331 ,(2001)
VAY LW Go, Alan F Hofmann, WHJ Summerskill, None, Pancreozymin bioassay in man based on pancreatic enzyme secretion: potency of specific amino acids and other digestive products Journal of Clinical Investigation. ,vol. 49, pp. 1558- 1564 ,(1970) , 10.1172/JCI106373
F. Reimann, L. Williams, G. da Silva Xavier, G. A. Rutter, F. M. Gribble, Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells Diabetologia. ,vol. 47, pp. 1592- 1601 ,(2004) , 10.1007/S00125-004-1498-0
J. T. McLaughlin, R. B. Lomax, L. Hall, G. J. Dockray, D. G. Thompson, G. Warhurst, Fatty acids stimulate cholecystokinin secretion via an acyl chain length-specific, Ca2+-dependent mechanism in the enteroendocrine cell line STC-1 The Journal of Physiology. ,vol. 513, pp. 11- 18 ,(1998) , 10.1111/J.1469-7793.1998.011BY.X
Sam X. Cheng, John P. Geibel, Steven C. Hebert, Extracellular polyamines regulate fluid secretion in rat colonic crypts via the extracellular calcium-sensing receptor Gastroenterology. ,vol. 126, pp. 148- 158 ,(2004) , 10.1053/J.GASTRO.2003.10.064
Yuri Sheinin, Enikö Kállay, Friedrich Wrba, Stefan Kriwanek, Meinrad Peterlik, Heide S. Cross, Immunocytochemical Localization of the Extracellular Calcium-Sensing Receptor in Normal and Malignant Human Large Intestinal Mucosa: Journal of Histochemistry and Cytochemistry. ,vol. 48, pp. 595- 601 ,(2000) , 10.1177/002215540004800503
J F Colombel, A Sutton, J A Chayvialle, R Modigliani, Cholecystokinin release and biliopancreatic secretion in response to selective perfusion of the duodenal loop with aminoacids in man. Gut. ,vol. 29, pp. 1158- 1166 ,(1988) , 10.1136/GUT.29.9.1158
Cecilia H. Chang, William Y. Chey, Qi Sun, Andrew Leiter, Ta-min Chang, Characterization of the release of cholecystokinin from a murine neuroendocrine tumor cell line, STC-1 Biochimica et Biophysica Acta. ,vol. 1221, pp. 339- 347 ,(1994) , 10.1016/0167-4889(94)90259-3