Role of calcium and other trace elements in the gastrointestinal physiology.

摘要: Calcium is an essential ion in both marine and terrestrial organisms, where it plays a crucial role processes ranging from the formation maintenance of skeleton to regulation neuronal function. The Ca(2+) balance maintained by three organ systems, including gastrointestinal tract, bone kidney. Since first being cloned 1993 Ca(2+)-sensing receptor has been expressed along entire until now exact function only partly elucidated. As this date still remains be determined if involved calcium handling tract. However, there are few studies showing physiological effects on gastric acid secretion fluid transport colon. In addition, polyamines amino acids have shown activate also act as allosteric modifiers signal nutrient availability intestinal epithelial cells. Activation colonic can abrogate cyclic nucleotide-mediated suggesting modifying secretory diarrheas like cholera. For many cell types changes extracellular concentration switch cellular behavior proliferation terminal differentiation or quiescence. cancer predominantly disease disordered between proliferation, termination apoptosis, disruption may contribute progression neoplastic disease. Loss growth suppressing elevated demonstrated colon carcinoma, correlated with level CaSR expression.