The Identification and Differentiation of Secondary Colorectal Cancer in Human Liver Tissue Using X-ray Fluorescence, Coherent Scatter Spectroscopy, and Multivariate Analysis

摘要: Secondary colorectal liver cancer is the most widespread malignancy in patients with cancer. The aim of this study to identify and differentiate between normal tissue malignant secondary using X-ray scattering fluorescence spectroscopy investigate best combination data that can be used enable classification these two types. (XRF) coherent scatter were collected for 24 tumor matched pair samples. levels 12 elements (P, S, K, Ca, Cr, Fe, Cu, Zn, As, Se, Br, Rb) measured all When comparisons made tissues, statistically significant differences determined K (p = 0.046), Ca 0.040), Cr 0.011), Rb 0.05). For spectra collected, three peaks due adipose, fibrous content, water content observed. amplitude, full width half-maximum, area under both found significantly higher tumors compared surrounding Soft independent modeling class analogy was performed XRF, scatter, elemental ratio separately, accuracy 20 unknown samples 50, 30, 80%, respectively. Further analysis has shown a XRF single combined model gave improved classification, an 85%.