Molecularly imprinted microparticles in lipid-based formulations for sustained release of donepezil.

摘要: Donepezil is a drug administered for Alzheimer's disease treatment, and it potential template molecule imprinted microparticles. The precipitation polymerization technique allows the synthesis of spherical microparticles, intermolecular interactions among molecularly polymers (MIPs) play promising role delineating delivery systems. Once that donepezil poorly-water soluble compound, lipid based-formulations (LBFs) may enhance its oral administration. Based on this, LBFs are useful vehicles to incorporate microparticles synthesized by polymerization. In these formulations, dissolved in lipids accessible adsorbate polymers, hydrophobic environment increases molecular recognition MIPs. formulations based MIPs using pure oleic acid as vehicle prolong vitro release up several hours Fickian diffusion mechanism, provides multiphasic pattern related heterogeneity binding sites. modulation from MIPs-based oil contribute decrease side effects, possibly regulating absorption rate gastrointestinal tract. These systems represent novel technological platform not only donepezil, but also variety therapeutics.