Associations of Maternal Urinary Cadmium with Trimester-Specific Blood Pressure in Pregnancy: Role of Dietary Intake of Micronutrients

作者: C. Osorio-Yañez , B. Gelaye , R. S. Miller , D. A. Enquobahrie , A. A. Baccarelli

DOI: 10.1007/S12011-016-0705-4

关键词: Mean arterial pressureEndocrinologyBlood pressureUnderweightPregnancy TrimestersConfidence intervalMicronutrientChemistryPregnancyUrinary systemInternal medicineInorganic chemistryClinical biochemistryBiochemistryEndocrinology, Diabetes and MetabolismBiochemistry, medicalGeneral Medicine

摘要: Previous studies revealed associations of urinary Cd (U-Cd), a chronic exposure biomarker, with blood pressure (BP) in non-pregnant adults. However, the evidence regarding trimester-specific pregnancy and U-Cd effect modification by dietary intake micronutrients is scarce. We randomly selected 653 women from Omega Study cohort. was quantified inductively coupled plasma mass spectrometry. Trimester-specific, systolic (SBP) diastolic (DBP) were determined employing standard protocols mean arterial (MAP) also calculated. Associations SBP, DBP, MAP tertiles (≤0.21; 0.22–0.41; ≥0.42 μg/g Cr) assessed using multivariable linear regression models. explored pre-pregnancy BMI (≤25 or >25 kg/m2) low/high intake. After adjusting confounders elevated (upper tertile) as compared those low (lowest (≥0.42 vs. ≤0.21 Cr, respectively) had reduced third trimester (−1.8; 95 % confidence interval (CI) = −3.1, −0.5 mmHg) second (−1.1; CI −2.3, −0.03 mmHg). A significant decrease third-trimester associated increased observed only among normal/underweight (BMI ≤ 25 high (calcium, magnesium, zinc, selenium). Notably, concentrations consumption zinc non-heme iron food sources. No differences found preeclamptic non-preeclamptic women. Our study provides that should be taken into account when assessing health effects pregnant

参考文章(57)
Dana B Barr, Lynn C Wilder, Samuel P Caudill, Amanda J Gonzalez, Lance L Needham, James L Pirkle, None, Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements. Environmental Health Perspectives. ,vol. 113, pp. 192- 200 ,(2005) , 10.1289/EHP.7337
S. K. Egan, S. S.-H. Tao, J. A. T. Pennington, P. M. Bolger, US Food and Drug Administration's Total Diet Study: intake of nutritional and toxic elements, 1991–96 Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment. ,vol. 19, pp. 103- 125 ,(2002) , 10.1080/02652030110071354
Mohsen Vigeh, Kazuhito Yokoyama, Fateme Ramezanzadeh, Mojgan Dahaghin, Tadashi Sakai, Yoko Morita, Fumihiko Kitamura, Hajime Sato, Yasuki Kobayashi, Lead and other trace metals in preeclampsia: A case–control study in Tehran, Iran Environmental Research. ,vol. 100, pp. 268- 275 ,(2006) , 10.1016/J.ENVRES.2005.05.005
Ruth E. Patterson, Alan R. Kristal, Lesley Fels Tinker, Rachel A. Carter, Mary Pat Bolton, Tanya Agurs-Collins, Measurement characteristics of the Women's Health Initiative food frequency questionnaire. Annals of Epidemiology. ,vol. 9, pp. 178- 187 ,(1999) , 10.1016/S1047-2797(98)00055-6
Agneta Åkesson, Thomas Lundh, Marie Vahter, Per Bjellerup, Jonas Lidfeldt, Christina Nerbrand, Göran Samsioe, Ulf Strömberg, Staffan Skerfving, Tubular and glomerular kidney effects in Swedish women with low environmental cadmium exposure. Environmental Health Perspectives. ,vol. 113, pp. 1627- 1631 ,(2005) , 10.1289/EHP.8033
Wei Feng, Xiaosheng He, Mu Chen, Siyun Deng, Gaokun Qiu, Xiaoliang Li, Chuanyao Liu, Jun Li, Qifei Deng, Suli Huang, Tian Wang, Xiayun Dai, Binyao Yang, Jing Yuan, Meian He, Xiaomin Zhang, Weihong Chen, Haidong Kan, Tangchun Wu, Urinary Metals and Heart Rate Variability: A Cross-Sectional Study of Urban Adults in Wuhan, China Environmental Health Perspectives. ,vol. 123, pp. 217- 222 ,(2014) , 10.1289/EHP.1307563
Lee S. Friedman, Elena M. Lukyanova, Yuri I. Kundiev, Zoreslava A. Shkiryak-Nizhnyk, Nataliya V. Chislovska, Amy Mucha, Alexander V. Zvinchuk, Irene Oliynyk, Daniel Hryhorczuk, Anthropometric, environmental, and dietary predictors of elevated blood cadmium levels in Ukrainian children: Ukraine ELSPAC group Environmental Research. ,vol. 102, pp. 83- 89 ,(2006) , 10.1016/J.ENVRES.2006.04.002
Sara Kathleen Egan, Philip Michael Bolger, Clark Dewitt Carrington, Update of US FDA's Total Diet Study food list and diets. Journal of Exposure Science and Environmental Epidemiology. ,vol. 17, pp. 573- 582 ,(2007) , 10.1038/SJ.JES.7500554
Maria Tellez-Plaza, Ana Navas-Acien, Ciprian M. Crainiceanu, Eliseo Guallar, Cadmium Exposure and Hypertension in the 1999–2004 National Health and Nutrition Examination Survey (NHANES) Environmental Health Perspectives. ,vol. 116, pp. 51- 56 ,(2007) , 10.1289/EHP.10764
Curtis D. Klaassen, Jie Liu, Bhalchandra A. Diwan, Metallothionein protection of cadmium toxicity. Toxicology and Applied Pharmacology. ,vol. 238, pp. 215- 220 ,(2009) , 10.1016/J.TAAP.2009.03.026