作者: C. Osorio-Yañez , B. Gelaye , R. S. Miller , D. A. Enquobahrie , A. A. Baccarelli
DOI: 10.1007/S12011-016-0705-4
关键词: Mean arterial pressure 、 Endocrinology 、 Blood pressure 、 Underweight 、 Pregnancy Trimesters 、 Confidence interval 、 Micronutrient 、 Chemistry 、 Pregnancy 、 Urinary system 、 Internal medicine 、 Inorganic chemistry 、 Clinical biochemistry 、 Biochemistry 、 Endocrinology, Diabetes and Metabolism 、 Biochemistry, medical 、 General Medicine
摘要: Previous studies revealed associations of urinary Cd (U-Cd), a chronic exposure biomarker, with blood pressure (BP) in non-pregnant adults. However, the evidence regarding trimester-specific pregnancy and U-Cd effect modification by dietary intake micronutrients is scarce. We randomly selected 653 women from Omega Study cohort. was quantified inductively coupled plasma mass spectrometry. Trimester-specific, systolic (SBP) diastolic (DBP) were determined employing standard protocols mean arterial (MAP) also calculated. Associations SBP, DBP, MAP tertiles (≤0.21; 0.22–0.41; ≥0.42 μg/g Cr) assessed using multivariable linear regression models. explored pre-pregnancy BMI (≤25 or >25 kg/m2) low/high intake. After adjusting confounders elevated (upper tertile) as compared those low (lowest (≥0.42 vs. ≤0.21 Cr, respectively) had reduced third trimester (−1.8; 95 % confidence interval (CI) = −3.1, −0.5 mmHg) second (−1.1; CI −2.3, −0.03 mmHg). A significant decrease third-trimester associated increased observed only among normal/underweight (BMI ≤ 25 high (calcium, magnesium, zinc, selenium). Notably, concentrations consumption zinc non-heme iron food sources. No differences found preeclamptic non-preeclamptic women. Our study provides that should be taken into account when assessing health effects pregnant