Ethylhydrazine hydrochloride as a tumor inducer in mice.
作者： Hidesuke Shimizu , Donald Nagel , Bela Toth
关键词: Incidence (epidemiology) 、 Hemangiosarcoma 、 Inducer 、 Lung 、 Hemangioma 、 Adenocarcinoma 、 Hemangiopericytoma 、 Pathology 、 Medicine 、 Adenoma
摘要: The lifetime administration of 0.0125% ethylhydrazine hydrochloride in drinking water to randomly bred Swiss mice, beginning at 7 weeks age, induced tumors the lungs and blood vessels. Eighty-eight percent treated females 62% males developed lung tumors, whereas among controls, incidence was 21% 23% males. In addition, blood-vessel rose from 5 60% 6 16% males, as compared with controls. gross light microscopic investigation showed adenomas adenocarcinomas angiomas angiosarcomas vessels characteristic appearance. This proves for first time tumorigenicity this chemical. environmental significance hydrazine derivatives is discussed obtained results.
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