Optimization and evaluation of Oridonin-loaded Soluplus®-Pluronic P105 mixed micelles for oral administration
作者： Zhongcheng Ke , Zhenghai Zhang , Hao Wu , Xiaobin Jia , Youjie Wang
DOI: 10.1016/J.IJPHARM.2016.12.047
关键词: Bioavailability 、 Micelle 、 Poloxamer 、 Particle size 、 Dialysis tubing 、 Chemistry 、 Oral administration 、 Drug 、 Pharmacokinetics 、 Chromatography
摘要: In this study, a new type of mixed micelles was developed using Soluplus® (SOL) and Pluronic® P105 (P105) for the encapsulation Oridonin (ORN). Oridonin-loaded (ORN-M) were simply prepared solvent evaporation characterized particle size, morphology, efficiency, drug loading. addition, in vitro release behavior ORN-M assessed widely applied dialysis bag technique. The pharmacokinetic property ORN explored rats after oral administration ORN-M. Optimized small size (137.2±1.65nm) spherical shape when ratio SOL:P105 3:1, with entrapment efficiency 90.48±1.85% loading 15.08±0.38%. Oral absorption capacity greatly enhanced relative bioavailability 210.55% comparison to that in-house suspensions, which suggests shows significantly improved characteristics. Overall, optimized SOL-P105 dual show great potential use as carriers cancer treatment.
sci-hub.se 参考文章(81)
M. Moffitt, L. Zhang, K. Khougaz, A. Eisenberg, Micellization of Ionic Block Copolymers in Three Dimensions Springer, Dordrecht. pp. 53- 72 ,(1996) , 10.1007/978-94-009-0333-3_4
Dajun D. Sun, Ping I. Lee, Probing the mechanisms of drug release from amorphous solid dispersions in medium-soluble and medium-insoluble carriers. Journal of Controlled Release. ,vol. 211, pp. 85- 93 ,(2015) , 10.1016/J.JCONREL.2015.06.004
Hanan M. El-Laithy, Emad B. Basalious, Boushra M. El-Hoseiny, Maha M. Adel, Novel self-nanoemulsifying self-nanosuspension (SNESNS) for enhancing oral bioavailability of diacerein: Simultaneous portal blood absorption and lymphatic delivery. International Journal of Pharmaceutics. ,vol. 490, pp. 146- 154 ,(2015) , 10.1016/J.IJPHARM.2015.05.039
Rotem Kedar, Ofra Sabag, Michal Licthenstein, Haya Lorberboum-Galski, Soluble CD40 ligand (sCD40L) provides a new delivery system for targeted treatment: sCD40L-caspase 3 chimeric protein for treating B-cell malignancies. Cancer. ,vol. 118, pp. 6089- 6104 ,(2012) , 10.1002/CNCR.27654
Hyun-Jong Cho, Jae-Young Lee, Wie-Soo Kang, Jingpei Piao, In-Soo Yoon, Dae-Duk Kim, Soluplus®/TPGS-based solid dispersions prepared by hot-melt extrusion equipped with twin-screw systems for enhancing oral bioavailability of valsartan Drug Design Development and Therapy. ,vol. 9, pp. 2745- 2756 ,(2015) , 10.2147/DDDT.S84070
Xiaoyu Wang, Jinyu Li, Xinggang Yang, Weisan Pan, Dandan Liu, Hao Pan, Fengwei He, Effect of particle size on oral absorption of carvedilol nanosuspensions: in vitro and in vivo evaluation International Journal of Nanomedicine. ,vol. 10, pp. 6425- 6434 ,(2015) , 10.2147/IJN.S87143
A. Ganji, A. Varasteh, M. Sankian, Aptamers: new arrows to target dendritic cells. Journal of Drug Targeting. ,vol. 24, pp. 1- 12 ,(2016) , 10.3109/1061186X.2015.1041962
Xudong Cheng, Hongmei Yan, Xiaobin Jia, Zhenhai Zhang, Preparation and in vivo/in vitro evaluation of formononetin phospholipid/vitamin E TPGS micelles Journal of Drug Targeting. ,vol. 24, pp. 161- 168 ,(2016) , 10.3109/1061186X.2015.1064435
Jian Huang, Lijun Wu, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima, Bcl-2 Up-Regulation and P-p53 Down-Regulation Account for the Low Sensitivity of Murine L929 Fibrosarcoma Cells to Oridonin-Induced Apoptosis Biological & Pharmaceutical Bulletin. ,vol. 28, pp. 2068- 2074 ,(2005) , 10.1248/BPB.28.2068
Abraham H. Abouzeid, Niravkumar R. Patel, Vladimir P. Torchilin, Polyethylene glycol-phosphatidylethanolamine (PEG-PE)/vitamin E micelles for co-delivery of paclitaxel and curcumin to overcome multi-drug resistance in ovarian cancer. International Journal of Pharmaceutics. ,vol. 464, pp. 178- 184 ,(2014) , 10.1016/J.IJPHARM.2014.01.009