Pharmacokinetics of chloramphenicol in non-lactating cattle.

摘要: The pharmacokinetics and bioavailability of a formulation chloramphenicol base in propylene glycol were determined following administration single intravenous (i.v.) subcutaneous (s.c.) 50 mg/kg doses to six non-lactating Holstein cows. Mean serum concentrations i.v. declined rapidly from peak greater than 100 μg/ml 6.9 μg /ml at 12 h after administration. Serum not detectable 24 administration. curve vs time was characteristic two-compartment open model. Mean data gave biological half-life 4.3 volume distribution the central compartment 0.44 1/kg. Serum s.c. rose slowly broad near 20 μ g/ml 3 8 then declined. These also analysed according 4.2 0.50 1/kg. Significant adverse reactions, including acute collapse, intravascular haemolysis haemoglobinuria, observed cows when dosed Cows exhibited local reactions injection sites. The disadvantages appear be significant may outweigh potential advantages parenteral use drug as presently formulated.