Pharmacokinetics of a long‐acting chloramphenicol formulation administered by intramuscular and subcutaneous routes in cattle

摘要: Sanders, P., Guillot, P. & Mourot, D. Pharmacokinetics of a long-acting chloramphenicol formulation administered by intramuscular and subcutaneous routes in cattle. J. vet. Pharmacol. Therap. 11, 183–190. The pharmacokinetic properties were determined six yearling cattle after single intravenous (i.v.) administration (40 mg/kg body weight) two sequential (s.c.) or (i.m.) administrations (90 mg/kg/48 h). The extra vascular studied during crossover trial for bioequivalence test. After i.v. administration, the plasma concentration-time graph was characteristic two-compartment open model. Mean values half-life 4.1 h, volume distribution 0.86 1/kg clearance 0.128 l/kg/h. Plasma concentrations following i.m. s.c. increased slowly to broad peak at 10–15 Hg/ml between 9 12 h. Bioavailability 19.1% injection 12.4% administration. extent absorption from did not differ significantly. rate significantly lower application than it injection. time necessary concentration exceed 5 μg/ml same routes. Thus, are bioequivalent.