Impact of Preexisting and Induced Humoral and Cellular Immune Responses in an Adenovirus-Based Gene Therapy Phase I Clinical Trial for Localized Mesothelioma

作者: Katherine L. Molnar-Kimber , Daniel H. Sterman , Michael Chang , Eugen H. Kang , Mohammed ElBash

DOI: 10.1089/HUM.1998.9.14-2121

关键词: Phases of clinical researchImmunologyGenetic enhancementRecombinant DNALocalized MesotheliomaBiologyImmune system

摘要: ABSTRACT Little is known about the immune responses induced by recombinant adenoviral (Ad) vectors in humans. The humoral and cellular were therefore analyzed 21 patients with l...

参考文章(42)
G A Prince, H S Ginsberg, The molecular basis of adenovirus pathogenesis. Infectious agents and disease. ,vol. 3, pp. 1- 8 ,(1994)
D D Porter, A B Jenson, R L Horswood, R M Chanock, H S Ginsberg, G A Prince, Pathogenesis of adenovirus type 5 pneumonia in cotton rats (Sigmodon hispidus). Journal of Virology. ,vol. 67, pp. 101- 111 ,(1993) , 10.1128/JVI.67.1.101-111.1993
M.F. White, C.R. Kahn, The insulin signaling system. Journal of Biological Chemistry. ,vol. 269, pp. 1- 4 ,(1994) , 10.1016/S0021-9258(17)42297-6
S C Wadsworth, H Zhou, A E Smith, J M Kaplan, Adenovirus vector-infected cells can escape adenovirus antigen-specific cytotoxic T-lymphocyte killing in vivo. Journal of Virology. ,vol. 71, pp. 5189- 5196 ,(1997) , 10.1128/JVI.71.7.5189-5196.1997
Hanne Gahéry-Ségard, Françoise Farace, Dominique Godfrin, Jesintha Gaston, Renée Lengagne, Thomas Tursz, Pierre Boulanger, Jean-Gérard Guillet, Immune Response to Recombinant Capsid Proteins of Adenovirus in Humans: Antifiber and Anti-Penton Base Antibodies Have a Synergistic Effect on Neutralizing Activity Journal of Virology. ,vol. 72, pp. 2388- 2397 ,(1998) , 10.1128/JVI.72.3.2388-2397.1998
M. Caruso, K. Pham-Nguyen, Y. L. Kwong, B. Xu, K. I. Kosai, M. Finegold, S. L. Woo, S. H. Chen, Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 11302- 11306 ,(1996) , 10.1073/PNAS.93.21.11302
T. E. Bureau, S. R. Wessler, Mobile inverted-repeat elements of the Tourist family are associated with the genes of many cereal grasses. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 1411- 1415 ,(1994) , 10.1073/PNAS.91.4.1411
D. Barba, J. Hardin, M. Sadelain, F. H. Gage, Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 4348- 4352 ,(1994) , 10.1073/PNAS.91.10.4348
Karen F. Kozarsky, James M. Wilson, Gene therapy: adenovirus vectors. Current Opinion in Genetics & Development. ,vol. 3, pp. 499- 503 ,(1993) , 10.1016/0959-437X(93)90126-A
Paul B. McCray, Guoshun Wang, Joel N. Kline, Joseph Zabner, Sunil Chada, Doug J. Jolly, Steven M. W. Chang, Beverly L. Davidson, Alveolar Macrophages Inhibit Retrovirus-Mediated Gene Transfer to Airway Epithelia Human Gene Therapy. ,vol. 8, pp. 1087- 1093 ,(1997) , 10.1089/HUM.1997.8.9-1087