Monoclonal Antibodies in Lymphoma Diagnosis and Classification.

摘要: The availability of monoclonal antibodies reactive with antigens present on leukocytes and leukocyte subpopulations has enabled a more reliable diagnosis precise subclassification malignant lymphomas. wide application frozen tissue sections makes one almost forget that the first anti T cell reagents were described in 1979 (1), applications such human lymph nodes by immunoperoxidase techniques 1981 (2). Since 1973 there had been significant progress histological classification lymphomas, was partly based careful cytological comparisons between cells lymphomas normal lymphoid tissues, an results immunological marker studies, derived from basic imnunology (3, 4). Among these studies demonstration complement receptors rosetting follicular 1974 (5) cytoplasmic immunoglobulin staining paraffin (6).