Molecular dynamics insights into human aquaporin 2 water channel
作者： A.R. Binesh , R. Kamali
DOI: 10.1016/J.BPC.2015.10.002
关键词: Aquaporin 2 、 Biochemistry 、 Biophysics 、 Chemistry 、 Aquaporin 、 Molecular dynamics 、 Lipid bilayer 、 Permeability (electromagnetism) 、 Water transport 、 Permeation 、 Tetramer
摘要: In this study, the first molecular dynamics simulation of human aquaporin 2 is performed and for a better understanding permeability performance, characteristics water transport in protein channel key biophysical parameters AQP2 tetramer including osmotic diffusive constants pore radius are investigated. For purpose, recently recovered high resolution X-ray crystal structure of` used to perform twenty nanosecond fully hydrated embedded lipid bilayer. The resulting showed that mean range comparison with other aquaporins family. Finally, results reported research demonstrate provided useful insights into mechanisms permeation urine concentration kidney.
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