Acute Changes in Frontoparietal Activity after Repetitive Transcranial Magnetic Stimulation over the Dorsolateral Prefrontal Cortex in a Cued Reaction Time Task
作者： Elisabeth Rounis , Klaas E Stephan , Lucy Lee , Hartwig R Siebner , A Pesenti
DOI: 10.1523/JNEUROSCI.2657-06.2006
关键词: Functional magnetic resonance imaging 、 Intraparietal sulcus 、 Ventrolateral prefrontal cortex 、 Posterior parietal cortex 、 Transcranial magnetic stimulation 、 Primary motor cortex 、 Neuroscience 、 Dorsolateral prefrontal cortex 、 Working memory 、 Psychology
摘要: Lesion and functional imaging studies in humans have suggested that the dorsolateral prefrontal cortex (DLPFC), ventrolateral (VLPFC), intraparietal sulcus (IPS) are involved orienting attention. A magnetic resonance study supplemented by a behavioral experiment examined effects of 5 Hz repetitive transcranial stimulation (rTMS) conditioning to right left DLPFC on reaction times synaptic activity as indexed changes blood oxygenation level-dependent (BOLD) signal during cued choice time task. Orienting precues were either correct (valid) or incorrect (invalid) with respect subsequent move cue. The real sham rTMS compared for each site stimulation. Invalid trials showed significant increase response increases BOLD frontal parietal regions when valid trials. Conditioning led decreased performance this reorienting task areas including VLPFC IPS. Comparing invalid after revealed VLPFC. Data from selectively This effect was only present first 10 min conditioning. No found validly invalidly These results suggest over exerts remote functionally interact attentional processes, particularly attention is more demanding
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