Cytarabine-AOT catanionic vesicle-loaded biodegradable thermosensitive hydrogel as an efficient cytarabine delivery system.
作者： Jing Liu , Yue Jiang , Yuting Cui , Chuanshan Xu , Xiaoqing Ji
DOI: 10.1016/J.IJPHARM.2014.07.032
关键词: Controlled release 、 In vivo 、 Vesicle 、 Cytarabine Hydrochloride 、 Drug 、 Combinatorial chemistry 、 Chemistry 、 Cytarabine 、 Amphiphile 、 Drug delivery 、 Chromatography
摘要: Carrier with high drug loading content is one of the most important issues in delivery system. In present work, an ion-pair amphiphilic molecule composed anticancer cation and surfactant anion used for straightforward fabricating vesicles cancer therapy. Anticancer (cytarabine hydrochloride) anionic (AOT) are selected fabrication molecule. One contains cation, thus 50% (mol/mol) theory. The vitro release study shows that time cytarabine about 3 times pure solution permeability has been improved 160 tested by parallel artificial membrane assay model. However, hemolytic toxicity largely decreased studied concentration range. cytotoxicity results show cytarabine-AOT amphiphiles have a much lower IC50 (drug resulting cell death) value higher inhibition rate comparing their respective components, indicating its effective therapy leukemic cells. To obtain longer convenient system, prepared further incorporated into thermosensitive PLGA-PEG-PLGA hydrogel to prepare subcutaneous administration. vivo indicate vesicle-loaded good injectable system controlled
sci-hub.se 参考文章(43)
Hussein I. El-Subbagh, Abdullah A. Al-Badr, Cytarabine Profiles of Drug Substances, Excipients and Related Methodology. ,vol. 34, pp. 37- 113 ,(2009) , 10.1016/S1871-5125(09)34002-9
U. Brohede, T. Bramer, K. Edsman, M. Strømme, Electrodynamic investigations of ion transport and structural properties in drug-containing gels: dielectric spectroscopy and transient current measurements on catanionic carbopol systems. Journal of Physical Chemistry B. ,vol. 109, pp. 15250- 15255 ,(2005) , 10.1021/JP0511350
E. Kaler, A. Murthy, B. Rodriguez, J. Zasadzinski, Spontaneous vesicle formation in aqueous mixtures of single-tailed surfactants Science. ,vol. 245, pp. 1371- 1374 ,(1989) , 10.1126/SCIENCE.2781283
Gaetano Giammona, Giovanna Pitarresi, Vincenzo Tomarchio, Gennara Cavallaro, Massimo Mineo, Crosslinked α,β-polyasparthydrazide hydrogels: effect of crosslinking degree and loading method on cytarabine release rate Journal of Controlled Release. ,vol. 41, pp. 195- 203 ,(1996) , 10.1016/0168-3659(96)01322-3
Daniela Cigognini, Diego Silva, Sara Paloppi, Fabrizio Gelain, Evaluation of mechanical properties and therapeutic effect of injectable self-assembling hydrogels for spinal cord injury. Journal of Biomedical Nanotechnology. ,vol. 10, pp. 309- 323 ,(2014) , 10.1166/JBN.2014.1759
Mingxi Qiao, Dawei Chen, Xichen Ma, Yanjun Liu, Injectable biodegradable temperature-responsive PLGA-PEG-PLGA copolymers : Synthesis and effect of copolymer composition on the drug release from the copolymer-based hydrogels International Journal of Pharmaceutics. ,vol. 294, pp. 103- 112 ,(2005) , 10.1016/J.IJPHARM.2005.01.017
D.R. Nogueira, M. Mitjans, M.R. Infante, M.P. Vinardell, The role of counterions in the membrane-disruptive properties of pH-sensitive lysine-based surfactants. Acta Biomaterialia. ,vol. 7, pp. 2846- 2856 ,(2011) , 10.1016/J.ACTBIO.2011.03.017
Maria G. Pallavicini, Cytosine arabinoside: Molecular, pharmacokinetic and cytokinetic considerations Pharmacology & Therapeutics. ,vol. 25, pp. 207- 238 ,(1984) , 10.1016/0163-7258(84)90044-5
Ashay Jain, Abhinav Agarwal, Saikat Majumder, Narendra Lariya, Anil Khaya, Himanshu Agrawal, Subrata Majumdar, Govind P. Agrawal, Mannosylated solid lipid nanoparticles as vectors for site-specific delivery of an anti-cancer drug Journal of Controlled Release. ,vol. 148, pp. 359- 367 ,(2010) , 10.1016/J.JCONREL.2010.09.003
Dolores R. Serrano, Leticia Hernández, Laura Fleire, Iban González-Alvarez, Ana Montoya, María P. Ballesteros, María A. Dea-Ayuela, Guadalupe Miró, Francisco Bolás-Fernández, Juan J. Torrado, Hemolytic and pharmacokinetic studies of liposomal and particulate amphotericin B formulations. International Journal of Pharmaceutics. ,vol. 447, pp. 38- 46 ,(2013) , 10.1016/J.IJPHARM.2013.02.038