Use of proteins as biomarkers and their role in carcinogenesis

摘要: Summary: Improved diagnostic methods and medical therapies are necessary for early detection treatment an improved prognosis. It is thus vital to both examine evaluate the role of various existing proteins as biomarkers in carcinogenesis assess contribution these anti-cancer activity, consideration therapeutic strategies. essential The purpose this review twofold. Firstly, it recent data about which can be utilized carcinogenesis. reviewed include: CPTP, IL-6, CCN, S100. Secondly, dietary cancer activity. Specifically, how whey protein, soy lectin, a phytochemical could useful prevention treatment. Recent Findings: Whey present dairy products, excellent source sulphur amino acid cysteine, rate limiting substrate glutathione synthesis. Notably, protein survives digestion has been shown have anti-carcinogenic properties animal studies. Lectins phytochemicals plant foods, active components alters initiation, promotion progression. characterized tool biochemistry, cell biology, immunology purposes research. Soy contain compounds, including isoflavones, protease inhibitors kinase inhibitors, proven effective tumor growth inhibition. They therefore, greatly emphasized treatment. proved that food consumption was associated with decreased risk death recurrence breast cancer. CPTP recently discovered whose main transport C1P, pro-inflammatory molecule. discovery may shine light on mechanism inflammatory diseases, hopefully offer potential target Interleukin-6 multifunctional cytokine affects activity cells. involved growth, elevated levels increased S100B well-established biomarker malignant melanoma, assessing load, stage prognosis patients disease. Other members family include S100A4, several malignancies S100A2, found some cancers. CCN group regulatory proteins, located extracellular matrix (maricellular). cellular adhesion, mitogenesis, chemotaxis, survival, wound healing. also able modulate signals influence skeletal development angiogenesis. Many functions related growth. Furthermore, interacts estrogen cancer, implicated ovarian