Emerging roles for LXRs and LRH-1 in female reproduction

摘要: Abstract Nutritional status is known to control female reproductive physiology. Many pathologies such as anorexia nervosa , dystocia and preeclampsia, have been linked body mass index metabolic syndrome. Lipid metabolism has also associated with ovarian, uterine placental functions. Among the regulators of lipid homeostasis, Liver X Receptors (LXRs) Receptor Homolog-1 (LRH-1), two members nuclear receptor superfamily, play a central role. LXRs are sensitive intracellular cholesterol concentration decrease plasma cholesterol, allowing considering them “cholesterol sensors”. LRH-1 shares many target-genes considered for long time real orphan receptor, but recent findings showed that phospholipids ligands this receptor. Acting in concert, could thus be slight modifications cellular balance, tightly maintaining their concentrations. These last years, use transgenic mice clarified roles these receptors physiological This review will focused on reproduction. Their contribution ovarian endocrine exocrine functions, well physiology discussed. The future challenge target prevent lipid-associated diseases women.