Progesterone receptors and ovulation.
作者： Orla M. Conneely
DOI: 10.1007/978-3-642-02062-9_3
关键词: Luteinizing hormone 、 Gene isoform 、 Receptor 、 Steroid hormone 、 Progesterone receptor 、 Nuclear receptor 、 Internal medicine 、 Endocrinology 、 Ovulation 、 Biology 、 Follicular phase
摘要: The steroid hormone, progesterone, plays a critical role in the regulation of female ovulation. physiological effects progesterone are mediated by two nuclear receptor transcription factors, PR-A and PR-B, which produced from single gene upon binding regulate expression specific networks reproductive tissues. Both null mutation PR to delete both proteins selective disruption isoform lead failure ovulation due disabled follicular rupture response gonadotrophin stimulation. Recent studies have revealed that LH stimulus triggers is transduced PRs residing mural granulosa cells induce paracrine signals interact with cumulus control matrix function expansion facilitate rupture.
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sci-hub.st 参考文章(31)
Orla M. Conneely, Biserka Mulac-Jericevic, John P. Lydon, Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms Steroids. ,vol. 68, pp. 771- 778 ,(2003) , 10.1016/S0039-128X(03)00126-0
B. Mulac-Jericevic, J. P. Lydon, F. J. DeMayo, O. M. Conneely, Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 9744- 9749 ,(2003) , 10.1073/PNAS.1732707100
Preeti M. Ismail, Jie Li, Francesco J. DeMayo, Bert W. O’Malley, John P. Lydon, A Novel LacZ Reporter Mouse Reveals Complex Regulation of the Progesterone Receptor Promoter During Mammary Gland Development Molecular Endocrinology. ,vol. 16, pp. 2475- 2489 ,(2002) , 10.1210/ME.2002-0169
Gopinath S. Palanisamy, Yong-Pil Cheon, Jaeyeon Kim, Athilakshmi Kannan, Quanxi Li, Marcey Sato, Srinivasa R. Mantena, Regine L. Sitruk-Ware, Milan K. Bagchi, Indrani C. Bagchi, A Novel Pathway Involving Progesterone Receptor, Endothelin-2, and Endothelin Receptor B Controls Ovulation in Mice Molecular Endocrinology. ,vol. 20, pp. 2784- 2795 ,(2006) , 10.1210/ME.2006-0093
U Natraj, J S Richards, Hormonal regulation, localization, and functional activity of the progesterone receptor in granulosa cells of rat preovulatory follicles Endocrinology. ,vol. 133, pp. 761- 769 ,(1993) , 10.1210/ENDO.133.2.8344215
Masayuki Shimada, Inmaculada Hernandez-Gonzalez, Ignacio Gonzalez-Robayna, JoAnne S. Richards, Paracrine and autocrine regulation of epidermal growth factor-like factors in cumulus oocyte complexes and granulosa cells: key roles for prostaglandin synthase 2 and progesterone receptor. Molecular Endocrinology. ,vol. 20, pp. 1352- 1365 ,(2006) , 10.1210/ME.2005-0504
Jaeyeon Kim, Indrani C. Bagchi, Milan K. Bagchi, Signaling by Hypoxia-Inducible Factors Is Critical for Ovulation In Mice Endocrinology. ,vol. 150, pp. 3392- 3400 ,(2009) , 10.1210/EN.2008-0948
Marco Conti, Minnie Hsieh, Jy-Young Park, You-Qiang Su, Role of the epidermal growth factor network in ovarian follicles. Molecular Endocrinology. ,vol. 20, pp. 715- 723 ,(2006) , 10.1210/ME.2005-0185
Biserka Mulac-Jericevic, Robert A Mullinax, Francesco J DeMayo, John P Lydon, Orla M Conneely, Subgroup of Reproductive Functions of Progesterone Mediated by Progesterone Receptor-B Isoform Science. ,vol. 289, pp. 1751- 1754 ,(2000) , 10.1126/SCIENCE.289.5485.1751
R. L. Robker, D. L. Russell, L. L. Espey, J. P. Lydon, B. W. O'Malley, J. S. Richards, Progesterone-regulated genes in the ovulation process: ADAMTS-1 and cathepsin L proteases Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 4689- 4694 ,(2000) , 10.1073/PNAS.080073497